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Preclinical studies showed that ramucirumab binds selectively to VEGFR2 with a greater efficacy than its natural ligand VEGF-A
This dual genetic control necessitates exquisite coordination between the nucleus and mitochondria to maintain cellular homeostasis
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Curr Opin Pharmacol (2007) 7:226.10.1016/j.coph.2006.07.005 218 SchloesserRJManjiHKMartinowichK
