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The enzyme glutathione reductase utilizes NADPH as a cofactor to reduce GSSG back to two moles of GSH
For instance, activation of Sirt1 reduced toxin-induced neuronal death, whereas inhibition of Sirt2 ameliorated S-mediated cell death in PD models (Figure 3) (Park et al., 2020)
The immune system is also affected by glutathione, with Treg cells helping to prevent autoimmune diseases.[ref] One pathway of estrogen metabolism involves glutathione[[ref] Heres a specific detox example: Mercury is a toxic heavy metal that is eliminated from the body in a glutathione-dependent manner
The CE-ICP-MS interface from [33] was installed at ICP-MS sample entrance providing electrical connection for the CE separation circuit and reduction of the undesired suction
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