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Serious Side Effects: Hypersensitivity or anaphylaxis (extremely rare), bronchospasm

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Immunosenescence is associated with dysregulated signaling pathways (e.g., overactivation of the NF-B signaling pathway and downregulation of the melatonin signaling pathway) and abnormal immune cell responses with functional alterations and phenotypic shifts

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Although WT -GCS-GS is nearly uninhibited by GSH (Ki 140 mM), shorter -GCS domain constructs were unexpectedly found to be strongly inhibited (Ki 15 mM), reproducing a physiologically important regulation seen in monofunctional -GCS enzymes