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During the passaging of MEF-Cas9 primary cells, we observed a significant increase in both protein and mRNA levels of p16 , as well as an increase in senescence-associated -galactosidase staining, indicating that MEF cells stably expressing Cas9 can normally undergo replicative senescence with passaging (Supplementary Fig

Simulating serpentinization as it could apply to the emergence of life using the JPL hydrothermal reactor

Its antioxidant and anti-inflammation effects are also useful when treating acne, rosacea, and hyperpigmentation

Proc Natl Acad Sci USA 96 : 73247329 Yakar S et al

Despite the obstacles, some small molecules mentioned in this review have already applied clinically, whose application in HTx can be quickly translated due to its confirmative safety and efficiency in human (Table 3)
