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A resource from THE BALANCE.

Compared to their offspring and matched controls, EL individuals exhibited a distinct metabolic profile characterized by higher levels of primary and secondary bile acidsmost notably chenodeoxycholic acid (CDCA) and lithocholic acid (LCA)lower levels of biliverdin and bilirubin, and stable levels of selected steroids

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If our data based on an intense and short exposure to HNE can be extended to an in vivo situation where low concentrations of HNE are produced on a long time scale, the present results suggest that although the amount of DNA adducts is low upon treatment by exogenous HNE, their formation could be favored upon oxidative stress