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The thioesterase (TE) domain is able to release the target peptide by either hydrolysis or cyclization 12,15,16 and is supposed to condense tetradepsipeptides, first to produce an octadepsipeptidyl- O -TE and then a decadepsipeptidyl- O -TE, followed by macrolactonization to form the cyclic twelve residue product cereulide 8,9

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Similarly, the healing of spinal cord injured rats through BPC 157 therapy is interesting, as very early, upon injury, there is a decrease of hematoma amid strongly elevated NOS-1, NOS-2, and NOS-3 gene expression (the mRNA expression studies) [170]

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