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10.1186/1750-1326-8-22 Mol

In vitro covalent neddylation assay was performed as described in the Methods section to determine the effects of Smurf1, Smurf1-C426A and Smurf1C699A on PDK1 neddylation in cell-free system

2 AD In the early 20th century, German psychiatrist Alois Alzheimer, using silver-staining techniques on the brain tissue of a patient with cognitive decline, first described two hallmark lesions: extracellular senile plaques composed of -amyloid deposits and intraneuronal neurofibrillary tangles ( The traditional amyloid cascade hypothesis posits that A oligomers are the central pathogenic initiators in AD

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