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Pineal melatonin can also directly modulate the sensitivity of the SCN to zeitgebers , thereby influencing the overall stability and adaptability of the circadian system

In addition, the concentric laminated pineal concretions are frequent observed [157,239] to be structurally similar the osteons (Figure 3), the major unit of compact bone

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The mechanisms underlying these changes in bile acid synthesis relate to changes in expression of the enzymes involved, and bile acids have been shown to be able to directly activate specific transcription factors that mediate such regulation