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Once injected into damaged tissue, stem cells can: Differentiate directly into the cell type needed (cartilage cells, tendon cells, etc.) Release growth factors and exosomes that activate surrounding cells Modulate immune responses to reduce inflammation Recruit additional repair cells to the injury site A 2025 Cochrane systematic review of stem cell injections for knee osteoarthritis examined 25 randomized trials with over 1,300 participants

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The pathogenesis of the immune-complex disease is not known for certain, but gold may behave as a hapten and generate the production of antibodies with subsequent deposition of gold protein-antibody complexes in the glomerular subepithelium