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[7] Although SPCD is an autosomal recessive condition, heterozygotes have been shown to be at an increased risk for developing benign cardiomyopathy compared to wild type individuals

Their prolonged usage can also be dangerous as they trigger your body to get used to them and would require increase in the dosage over the time

Sources: Kraemer, W

115(5): 5116 Lowes S, Rose ME, Mills GA
