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Nutritional deficiency is caused by a lack of the vitamin in the diet, whereas acquired deficiency occurs when the intestinal absorption of the vitamin is interfered with by diseases and conditions such as pernicious anemia (an autoimmune disorder affecting intrinsic factor protein produced by gastric parietal cells), chronic atrophic gastritis, Crohn's and celiac diseases, gastric bypass surgery, and medications such as metformin, gastric acid secretion blockers (i.e., proton-pump inhibitors and H2-receptor antagonists), and others (2, 3)

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Overall, the evidence supports the use of B12, on its own or in addition to other supplements, for the reduction of homocysteine levels

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Potential Benefits (mostly preclinical) Lipolysis (preclinical): Animal and lab studies report stimulation of fat breakdown and inhibition of fat formation [2] [5]