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Similarly, in azoxymethane-induced colon carcinogenesis in Balb/C mice, luteolin reduced MMP-9 and MMP-2 levels, suppressed tumor progression, and elevated TIMP-2 expression, demonstrating antimetastatic and chemopreventive effects at a 1.2 mg/kg daily oral dose [133]

PloS One 9 , e111585 (2014)

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A systematic review with meta-analysis

For instance, partial inhibition of GlyT2 could interfere with inhibitory glycinergic signaling, while residual affinity for SLC6A7 may alter L-proline homeostasis and glutamatergic tone, especially in limbic regions (Bae et al