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Cells can usually tolerate mild oxidative stress by additional synthesis of various antioxidants (glutathione, antioxidant enzymes, etc.) in an attempt to restore antioxidant/oxidant balance

The extensive R-domain and NBD1 interactions increase the ATPase rate in a manner consistent with CFTR, where R-domain phosphorylation potentiates ATP binding and hydrolysis but otherwise does not induce transport activity alone 34