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Expanding the use of 3D models in MET-targeted preclinical research is therefore likely to provide data that will better inform in vivo and clinical testing

Duration of treatment depends on the underlying cause: Lifelong therapy is required for pernicious anaemia or irreversible malabsorption (e.g., after gastrectomy) For dietary deficiency without malabsorption, treatment may be reviewed once deficiency is corrected and neurological symptoms have resolved Oral B12 supplementation is generally not recommended for patients with neurological symptoms, particularly when pernicious anaemia is the cause

Where literature is mixed or evidence is preliminary, the article hedges rather than overclaims

doi: 10.2174/1381612043383944

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