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More importantly, this gentler processing preserves the structural integrity of the delicate immunoglobulins, lactoferrin, and the crucial disulfide bonds of cystine required for glutathione synthesis

Furthermore, hypoxia influences various epigenetic mechanisms, including antigen presentation, cellular stress responses, DNA methylation, and histone methylation, which collectively affect Tregs function within the TME (Macedo-Silva et al., 2019)

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Of a consecutive sample of 3988 discharged patients, 1555 were excluded (796 declined to participate and 759 were unable to be contacted) and the remaining 2433 patients were enrolled

BMC Anesthesiol (2019) 19:32