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A thickened tunica is almost never included in traditional Peyronies definitions, but we found its prevalence to be nearly 35% among treated cases, and it causes the same negative side effects as fibrosis

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As an alternative methyl donor, betaine plays a central role in maintaining methylation capacity, and its depletion may contribute to elevations in S-adenosylhomocysteine and impaired methyltransferase activity

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