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Clinical trial number Not applicable Graphical Abstract Similar content being viewed by others Introduction Autism spectrum disorder (ASD) is a multifactorial neurodevelopmental condition characterized by a broad spectrum of symptoms, including impairments in social interaction and communication, alongside restricted, repetitive patterns of behavior, interests, or activities [1, 2]

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Studies in Crat knockout mice demonstrated that CrAT deficiency leads to abnormal fuel selection, which results in a perturbation of glucose homeostasis and suggest that deficits in CrAT activity might contribute to diet-induced metabolic inflexibility by exacerbating the Randle glucose-fatty acid cycle 66
