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In TMJ, this occurs through autonomic nervous system dysregulation

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5.1 Phytochemicals Rutin, also known as quercetin-3- O -rutinoside or rutoside, is a multifunctional bioflavonoid recognized for its wide-ranging health benefits, particularly its antioxidant, anti-inflammatory, and vascular-protective effects (Madkour et al., 2024)

Although it is not exactly clear how GPx1 upregulation is affecting NMDA activity following kainic acid, exposure of GPx1 overexpressing neurons grown in culture caused an accumulation of GSSG in the media, compared to the effects of kainic acid on wildtype neurons

P1329, P1330 Chen H.-Y