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(2024), Hofmann, F

4), in presence of various concentrations of the tested compounds, the enzymatic activity was determined by the standard assay

This is what makes once-weekly dosing effective
Considering that chemotherapy drugs have toxicity and side effects on other organs, are not targeted, and cannot be detected, we need a drug delivery platform to use them

J Mol Biol 1984;174(3):483-96
