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In pregnant women, vitamin B12 deficiency can cause birth defects and developmental delays

In December 2024, the FDA's Pharmacy Compounding Advisory Committee declined to include it on the 503A bulk drug substances list, meaning compounding pharmacies in the United States cannot legally produce it for individual prescriptions

The National Institute of Health (NIH) shares that the recommended dietary allowance (RDA) for vitamin B12 is: Infants 06 months: 0.4 microgram Infants 712 months: 0.5 microgram Toddlers 13 years: 0.9 microgram Children 48 years: 1.2 micrograms Children 913 years: 1.8 micrograms Adult men and women over age 14: 2.4 micrograms Women who are pregnant: 2.6 micrograms Women who are breastfeeding: 2.8micrograms For adults over 50 years old, the NIH recommends taking a daily vitamin B12 supplement or consuming foods fortified with vitamin B12

The medication should be kept in its original vial with the original labeling intact

This makes it a highly targeted tool for metabolic research