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Neuron 19:12971308 Bowman CL, Kimelberg HK (1984) Excitatory amino acids directly depolarize rat brain astrocytes in primary culture

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Specifically, while Nrf2 activation is protective in acute MIRI, its sustained or non-selective overactivation may promote cancer cell proliferation and drug resistance by regulating the expression of antioxidant genes, thereby helping cancer cells resist oxidative damage caused by chemotherapy drugs and enhancing their survival capabilities (Nezu and Suzuki, 2021

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