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This stress damages melanocytes directly, causes mitochondrial dysfunction, and triggers what scientists call the unfolded protein response (UPR) an internal alarm system inside cells

They work through different mechanisms and can produce synergistic effects

Discontinue use if irritation develops

What the Clinical Data Shows In Phase IIb clinical trials, participants taking 1 mg of AOD-9604 daily alongside diet and exercise lost an average of about 6 lbs over 12 weeks, compared to under 2 lbs in the placebo group with the peptide directly stimulating fat breakdown and inhibiting new fat storage, and without raising IGF-1 or disrupting glucose. John Comandari, Beyond Stem Cells Notice what that data tells us: the effect is real but modest , and it works best alongside diet and exercise, not as a replacement for them

doi: 10.1016/j.freeradbiomed.2024.06.014 50 MishimaENakamuraTZhengJZhangWMouroASDSennhennPet al