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One review of 3 studies in 151 people with IBS, some of whom experienced constipation, found that aloe vera drinks and tablets of aloe extract significantly improved their IBS symptoms, compared with a placebo ( The review authors also noted that aloe vera was safe for the short-term treatment of IBS

Metabolic disturbances identified in plasma are associated with outcomes in patients with heart failure: diagnostic and prognostic value of metabolomics
All values were significantly higher than the mean concentration in the control group (4.3 mol/l)
doi: 10.1007/s00401-013-1191-9
