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In the Xu 2024 heart-failure study the compound improved cardiac function rather than worsening it

Identification and structure-function analysis of subfamily selective G protein-coupled receptor kinase inhibitors

The reduction of GPX4 leading to lipid peroxidation may play a role in myofibroblast differentiation and the development of PF [59]

doi: 10.1074/jbc.RA118.006628

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