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The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling

MOTS-C is a 16-amino-acid peptide that lives inside your mitochondria, where it activates AMPK and pushes cells to burn fat for fuel
The thought is that they are triggered by an inflammatory reaction, such as injections (hence why they often occur between the shoulder blades or on top of the neck)

A 2018 study by Sircar et al
