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R-alpha-lipoic acid, the naturally occurring form, may offer advantages over synthetic alpha-lipoic acid, which contains both R and S enantiomers

Indeed, drug resistance is also related to increase discharge (efflux) of anticancer drugs due to the overexpression of the efflux transporters

DOI: 21

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[DOI] [PMC free article] [PubMed] [Google Scholar] 93.Fullerton M., McFarland R., Taylor R.W., Alston C.L