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J Pediatr Hematol Oncol (2008) 30:34752

2023;12(3):e220211

27 CataleC.BisicchiaE.CarolaV.ViscomiM

Products with 1-2% GHK-Cu concentration in stable formulations with appropriate pH and penetration enhancers create stronger improvements more likely persisting after treatment, while lower concentrations (0.1-0.5%) or degraded products may produce subtle temporary effects disappearing quickly upon discontinuation

In addition, MOTS-c was also found to have the same effects in an acute lung injury model, reducing pulmonary edema and inhibiting lung tissue neutrophil infiltration through downregulation of cytokine-induced neutrophil chemotactic factor-1 (CINC-1) and intercellular adhesion molecule-1 (ICAM-1) expression in lung tissue [45]