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Disruption of the NF-kappaB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-alpha and blocks the septic response in mice

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While the changes observed in Agrp and Pomc transcript levels in response to Gly-Low treatment predict activation of ghrelin signaling, ghrelin- associated genes Gh (growth hormone), Ghsr (growth hormone secretagogue receptor), and Ghrhr (growth hormone releasing hormone receptor) were all downregulated ( Figure S4A )