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At the level of gene transcription, the fact that three different proteins can be synthesized from gpx4, due to the presence of multiple transcriptional start sites, yielding the mitochondrial (m-), nuclear (n-), and cytosolic (c-) GPx4 forms, makes the issue of gene regulation extremely complex 54

Using gene knockdown and overexpression approaches, they further showed that silencing HIF-1 or HIF-2 significantly reduced hypoxia-induced LDHA expression (231)

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Intervention with vitamins in patients with nonproliferative diabetic retinopathy: a pilot study

In the single-time-point study, Tsubone et al