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However, their wide clinical usage is hindered by their pronounced side effects, specifically gastric ulcerations, renal damage, and cardiovascular thrombotic events (Drini 2017

Friedreichs ataxia (FRDA) is a neurodegenerative disease caused by a defect in mitochondrial frataxin (FXN), a key regulator of ferroptosis, and patients with FRDA are predisposed to diabetes (80)
