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describe and define (quantitatively to the extent possible) the variability and uncertainty for key assumptions used for each key end-point-specific risk assessment (choices of data set, POD, model, and dose metric)

The area under the blood concentration-time curve (AUC) is proportional to the dose and the extent of bioavailability for a drug if its elimination is first-order ( Figure 34 )

However, no difference was found between the two groups when comparing changes in total glutathione levels (responders p = 0.05, non-responders p = 0.06) (Table 4)

doi: 10.1021/ACSCHEMNEURO.1C00477 77 JungSAllaliGBenzakourLNuber-ChampierAThomassonMJacot de AlcntaraIet al

Soon San Francisco Bay had many hundreds of abandoned ships anchored off shore