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This work was financially supported in part by the Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) Grant Number JP20am0101072 from AMED, Japan, and JSPS KAKENHI Grant Numbers JP20H03191 and JP19H04856 and performed under the Collaborative Research Program of the Institute for Protein Research, Osaka University (CR-20-02 and CR-21-02)