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Biochemical factors that contribute to a proteins druggability include protein-class (membrane-bound 19,31 , or soluble and secreted ligands 32 , for example), current understanding of its pathophysiology and molecular function, its cellular location, and the presence of drug binding sites

doi: 10.1194/jlr.R048975

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But because theyre mostly anecdotal, its difficult to know whats truly caused by the compound, how common these effects are, or how much is tied to product quality or dosing variability

In a first step, we tested whether the 3' region or the introns are relevant for TRY function by transforming try mutant plants with a 1.8 kb 5' region that was fused to the TRY CDS (Figure 1, pTRY -A, B:c TRY try-JC )