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Furthermore, acetylcholine-induced production of bioavailable nitric oxide was lower in aortic rings from GPx1 / ApoE mice than ApoE / mice, and the double knockout mice had increased 3-nitrotyrosine staining in atheromatous plaques, similar to earlier findings of endothelial dysfunction in GPx1-deficient mice [39, 70, 71]

Specifically, the addition of cuprizone (bis-cyclohexanone oxalydihydrazone), to the diet process (66) produces a massive demyelination in different areas of the CNS and particularly in the corpus callosum (67-69)

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Figure 12-1 Visualization of impact of cLTP on PSDs and GluA1 expression in the postsynaptic density in primary hippocampal cultures and GluA1 expression in OHSCs

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