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Description
Nephropathy: ("Nephropathy" OR "Kidney Disorder" OR "Renal Disorder") 5
Animal Data In female rats given 5 mg/kg/day, 15 mg/kg/day and 50 mg/kg/day before mating and continuing through to gestation day 7 resulted in decreased fetal body weight (female pups) and delayed ossification at 50 mg/kg/day (10 times the human exposure at the MRHD dose of 40 mg/day based on AUC)
Density and wrinkle changes appear at 8 to 12 weeks
Too little inflammation and the repair process never properly initiates
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