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[DOI] [PubMed] [Google Scholar] 184.OConnor E.A., Evans C.V., Ivlev I., Rushkin M.C., Thomas R.G., Martin A., Lin J.S
DNA-bound elastase of neutrophil extracellular traps degrades plasminogen, reduces plasmin formation, and decreases fibrinolysis: proof of concept in septic shock plasma

Although these agents have demonstrated efficacy in inflammatory arthritides such as rheumatoid arthritis 20,21 , their utility in OA remains limited, largely because OA is a mechanically and biologically heterogeneous disease not driven by a single inflammatory pathway

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1984;247(1 Pt 1):E416