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Adipose triglyceride lipase-null mice are resistant to high-fat dietinduced insulin resistance despite reduced energy expenditure and ectopic lipid accumulation

Of these studies, four articles described treatment in cohorts, which had a peripheral polyneuropathy of any cause, seven studied treatment in diabetic neuropathy, two in chemotherapy induced peripheral neuropathy, and two in alcohol-related neuropathy

It plays a crucial role in cell growth, carbohydrate metabolism and fatty acid synthesis, playing a key role in supporting overall health

However, these compounds lack specificity and demonstrate off-target effects and a poor oral pharmacokinetic profile (8, 102)

This is not a universal contraindication but it warrants a specialist conversation