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Macrophage-hitchhiking interleukin-10 plasmid DNA delivery system modulates rheumatoid arthritis microenvironment via the re-polarization of macrophages

Aquat Toxicol 101:1330 [DOI] [PubMed] [Google Scholar] Lushchak VI (2014) Free radicals, reactive oxygen species, oxidative stress and its classification

This interaction results in the production of neuropeptides, gut hormones, neurotransmitters, and microbe-associated molecular patterns (MAMPs)

Lower-dose maintenance and full discontinuation produce different outcomes

| Target Concentration | BAC Water to Add | Dose per 10 units on syringe | |---------------------|-----------------|------------------------------| | 5mg/ml | 2.0ml | 0.5mg | | 10mg/ml | 1.0ml | 1.0mg | **Best for:** Patients on 1-2mg weekly doses during titration weeks 1-8
