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doi: 10.1186/s13041-021-00803-9 329 Di PatrePLReadSLCummingsJLTomiyasuUVartavarianLMSecorDLet al

"Using biochemistry and biophysics to extinguish androgen receptor signaling in prostate cancer"

A two-hit theory explains the mechanism of NASH pathogenesis, wherein simple fat accumulation in the hepatocytes (first hit) converts to lipotoxicity (second hit) with increased levels of free fatty acids, cholesterol and other lipid metabolites (Prez-Carreras et al., 2003

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Furthermore, we assessed the presence of the risk of bias, inconsistency or unexplained heterogeneity, indirectness of evidence, imprecision, and publication bias