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Life stage matters
186 Similarly, lactate from patient-derived GSCs and microglia/macrophages triggers histone Kla, boosting transcriptional upregulation of CD47 in GBM cells, ultimately suppressing phagocytosis and inducing immunosuppressive programs
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Among these molecules, we find micronutrients produced by endogenous synthesis but which can be insufficient in certain stages of life or under pathological or pharmacological conditions
Pharmacol Ther 221:107797
