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(b) a transcellular pathway, mainly across the sustentacular cells, most likely by receptor-mediated endocytosis, fluid-phase endocytosis, or passive diffusion (not for peptides)
Kramer, K., Dijkstra, H

Notably, preeclampsia resolves after delivery (Redman, 1991)

Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1
