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These reactive species attack cellular components and are responsible for several skin disorders (hyperpigmentation, aging prematurely...)

Additionally, conjugated BAs (e.g., TCA, TCDCA), whose levels are influenced by microbial BSH activity, can directly suppress macrophage IL-6 production, a key cytokine in the TIME (38)

doi: 10.1007/9781-49392684-8_13 52 GilmozziV.GentileG.RiekschnitzD

2013;4(5):e626

Enhance the binding of benzodiazepines
