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doi: 10.1093/toxsci/kfi211

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The first is conflating injectable and topical dosing conventions applying an injectable milligram-target approach to a topical protocol that should use concentration-based formulation, or vice versa

Abstract Hypertension is the most prevalent cause of cardiovascular disease and kidney failure, but only about 50% of patients achieve adequate blood pressure control, in part, due to inter-individual genetic variations in the response to antihypertensive medication

Cysteine synthesis via the transsulfuration pathway and GSH biosynthesis occurs primarily in the liver in physiological conditions, while in the pathology other cells can take over the same role or contribute to it (developed later in next paragraph)
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