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Xing L, Zheng H, Cao Y, Che S

Poor growth rates and ill thrift may be seen in affected animals

Among the main obstacles, particularly concerning oral administration, are low solubility, reduced intestinal absorption, hepatic first-pass metabolism, degradation during gastrointestinal transit, interactions with the food matrix, and high individual variability, including the influence of the intestinal microbiota [50]

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10.1136/gutjnl-2014-308430 129
