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The objective of this review is to provide a comprehensive and structured synthesis of the immunopathogenesis of HT, integrating established knowledge with emerging research areas including oxidative stress, gut microbiota, and epigenetic modifications, while also summarizing current clinical, diagnostic, and therapeutic perspectives (Fig

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Can J Physiol Pharmacol 94:10401047

Nevertheless, our results provide a glimpse into the complexity of MdDS manifestationshow patients appraise the severity of their MdDS condition is deeply personal with varied emphases on different symptoms