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Crystals can be taken up by mesenchymal dendritic cells via phagocytosis, a process that triggers the assembly and activation of NLRP3 inflammatory vesicles, leading to the release of IL-1, which in turn triggers the release of NF-kB-dependent cytokines and chemokines, amplifying the inflammatory response [323]

A Small Molecule Inhibitor of Nicotinamide N-Methyltransferase for the Treatment of Metabolic Disorders

Their systematic application to the PPP, for example, to manipulate G6PD and 6PGD in T cells, should be highly informative, especially as initial data suggest that these oxPPP enzymes may sometimes have opposite immunological functions

Iodide has been found to be highly efficient in scavenging reactive oxygen species (ROS), thus reducing damage caused by free oxygen radicals (52)

Antiaging, brightening, and antioxidant efficacy of fermented bilberry extract (vaccinium myrtillus): a randomized, double-blind, placebo-controlled trial