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The gut is one of the most peptide-responsive tissues in the body

As MS progresses, there is an increase in the proportion of chronically-demyelinated lesions at the expense of myelinated lesions (55)

Taken together, these considerations suggest that in situ conditions in the synapse are different from in vitro reconstituted conditions and prevent a gain-of-function phenotype in the former, but not in the latter case

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