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One disadvantage of the above described techniques for nose-to-brain drug delivery is that drugs are delivered to the entire brain unspecifically, whereas most CNS diseases primarily affect certain brain regions or cell types

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Those non-covalent compounds are highly specific and since they bind reversibly, they may exhibit a better safety profile ( in vivo activity (Zhuang et al., 2017), potentially because they are highly polar and hardly able to penetrate the BBB

Resveratrol ameliorates methotrexate-induced hepatotoxicity in rats via inhibition of lipid peroxidation

Scir et al., 2019