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In a recent study, increased Phactr4 expression was found within the hippocampus of rats induced to depression-like behavior through exposure to unpredictable chronic mild stress and these effects were reversed through hippocampal downregulation of Phactr4 , likely mediated by reduced neuroinflammation and improved synaptic plasticity 45

In addition, large Maf protein such as c-Maf can bind to ARE as homodimers and heterodimers with small Mafs (but not Nrfs) to repress ARE-mediated gene expression [151]

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ISSN 1664-3224.CS1 maint: extra punctuation (link) McGarry, Frances