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doi: 10.3389/fimmu.2015.00635 28 ChakrabortyBByemerwaJKrebsTLimFChangC-YMcDonnellDP

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Administered via the nose-to-brain drug delivery (NBDD) pathway, BA-LP demonstrates significant brain targeting and enhanced bioavailability, thereby improving drug efficacy and offering a novel therapeutic strategy for ischemic stroke (Xiang et al., 2020) has been shown to mitigate allergic rhinitis (AR) symptoms in rat models by inhibiting the release of immunoglobulin E (IgE), histamine, interleukin-1, interleukin-4 (IL-4), interleukin-6 (IL-6), and tumor necrosis factor- (TNF-) ( 2.1.2 Baicalein Baicalein and baicalin are flavonoids extracted from the rhizome of the traditional Chinese medicine Scutellaria baicalensis, with distinct differences in chemical structure and biological activity

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These signatures or fingerprints vary across trials but demonstrate the utility of metabolomics for prognostication as well as certain overarching traits when individual metabolites do not reach significance